microRNAs (miRNAs) are small non-coding RNAs (~22 nt) that regulate gene expression post-transcriptionally. In lung cancer, aberrant miRNA expression drives tumorigenesis, metastasis, and drug resistance—making them valuable biomarkers.
Oncogenic miRNAs
0
Upregulated, promote tumor growth
Tumor Suppressor miRNAs
0
Downregulated, inhibit tumor growth
TCGA miRNA-Seq Samples
989
1,046 miRNAs profiled
Overexpressed miRNAs that target tumor suppressor mRNAs. Examples: miR-21 targets PTEN/PDCD4; miR-155 modulates immune response. High expression correlates with poor prognosis.
Downregulated miRNAs that normally repress oncogenes. Examples: let-7 targets RAS/MYC; miR-34a is a p53 target. Restoration therapies (miR mimics) are in clinical trials.